Palmitoylethanolamide (PEA) is a fatty matter produced in the body in addition to found in concentration from food counting organ meats, olive oil, safflower chicken egg yolk, and soy lecithin, peanuts, and numerous others.
PEA is technically referred to as a “pro-resolving lipid signaling molecule.” What this means is that throughout impacting central control mechanism within our cells, PEA has a capability to resolve inflammation plus cellular stress. This tremendously beneficial effect has been verified in over 600 scientific studies.
What are the Clinical Applications of PEA?
PEA has widespread possible clinical applications because of its exclusive effects on factor that control cell function. The main clinical study focused on PEA has been in the treatment of pain plus inflammation. In that region of focus, there have been as a minimum 21 clinical trials with PEA. These studies had an array of 20 to 636 patients and PEA was used for period ranging from 14 days to 120 days. The Palmitoylethanolamide dosage ranged from 300 mg to 1200 mg daily. The administration form of PEA was in the majority cases oral tablets plus most common form of assessment for pain was the visual analog scale (VAS), wherever the patient makes a subjective evaluation of her/his pain level on a scale of 0 to 10 wherever 0 is no pain and 10 is the worst possible pain.
The most current study with PEA was in the treatment of osteoarthritis of the knee. The 111 participant were randomized to obtain 300 mg PEA, 600 mg PEA otherwise placebo every day for 8 weeks. In the groups getting PEA, there was an important reduction in the entire symptom scores for knee osteoarthritis in addition to the individual score for pain, stiffness, plus function in addition to anxiety. There were no side effects with PEA in this study. Whereas the 300 mg per day dose was effective, the 600 mg per day Palmitoylethanolamide dosage was even more so. Given its lack of side effects, the upper dosage is suggested.
The potential clinical application of PEA are fairly broad, but research plus popular use have focused on its use as an anti-inflammatory as well as pain-relieving agent in circumstances like low back pain, osteoarthritis, sciatica, etc. Preclinical and human studies have moreover investigated its effects on depression, boosting mental function plus memory, autism, manifold sclerosis, obesity, plus metabolic syndrome. While it shares several features comparable to cannabidiol (CBD), the benefit of PEA is that it has better science toward support its use.